Abstract

Background Pancreatic damage is a common digestive system disease with no specific drugs. Static magnetic field (SMF), the key component of magnetic resonance imaging (MRI), has demonstrated prominent effects in various disease models. Purpose To study the effects of 0.1–9.4 T SMFs on pancreatic injury induced by alcohol, and acute pancreatitis (AP) induced by L‐arginine (L‐Arg). Study Type Prospective, animal model. Animal Model Twelve healthy C57BL/6J male mice, 30 AP model male mice, and 30 alcohol‐associated liver disease (AALD) model male mice. Field Strength/Sequence 1.5–9.4 T SMFs for 12 hours and 0.1 T SMF for 72 hours. No imaging sequence was used. Assessment Histological analysis on AALD mice pancreas was conducted. For L‐Arg‐induced AP mice, their body weight, food/water consumption, open field behavior, blood analysis, as well as histological analysis, inflammatory, oxidative stress of the pancreas were measured. In vitro cellular experiments were also conducted. Statistical Tests Data are presented as means ± SD and analyzed using the two‐tailed Student's t ‐test or one‐way analysis of variance (ANOVA) test. P values <0.05 were considered statistically significant. Results 1.5–7 T SMFs significantly reduced alcohol‐induced pancreatic damage, increasing the structurally intact acinar area from 51.5% to 78.3%, whereas the effect of 9.4 T SMF is not obvious. 0.1 T SMF can reduce the AP mice lethality, increase the structurally intact acinar area from 31.0% to 59.7%, associated with the reduced pancreatic inflammatory responses (78.1% reduction of F4/80 and 80.0% reduction of MPO), 20.0% decreased oxidative stress and 53.2% reduced pancreatic cell apoptosis. Data Conclusion High‐field MRI may be safe for pancreatic‐related diseases at the animal level. SMFs have a future potential to be developed as non‐invasive and highly penetrating physical modalities for the treatment of pancreatic injury including AP. Plain Language Summary This study aims to evaluate the safety and potential therapeutic effects of moderate‐ to high‐intensity static magnetic fields (SMFs) on mice with pancreatic injury. Their findings revealed that SMFs between 1.5 and 7 Tesla (T) helped reduce alcohol‐induced pancreatic damage, while a stronger 9.4 T showed no effect. Interestingly, for mice with L‐arginine‐induced acute pancreatitis, a weaker 0.1 T significantly increased the area of healthy acinar cells from 31.0% to 59.7%. These results not only suggest that MRI‐related SMFs are safe for pancreatic diseases in animals, but also unravel the potential of SMFs as a future treatment option for pancreatic disorders. Evidence Level N/A Technical Efficacy Stage 1