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Brain delivery of therapeutic proteins using an Fc fragme... | ResearchHub

Paper

Paper

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Journal

Science Translational Medicine

Topics

DOI

10.1126/scitranslmed.aay1359

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

2

Authors

Mihalis Kariolis

Mihalis Kariolis•Robert Wells•Y. Zuchero

Published

May 27, 2020

Abstract

Engineering human IgG1 Fc binding to a brain endothelial cell–enriched receptor allows enhanced brain exposure of biotherapeutics in multiple species.

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Journal

Science Translational Medicine

Topics

DOI

10.1126/scitranslmed.aay1359