$10,000of $10,000
Proposes a preregistered UK Biobank secondary analysis comparing metformin users to matched non-users on glymphatic/diffusion MRI, abdominal MRI, NMR metabolomics, and cognition. Fits the RFP's cognitive enhancement track only indirectly since metformin is a small molecule, not a peptide. Strong open-science design and PI expertise, but observational confounding and a tight cloud budget limit causal and operational confidence.