Katharina Maisel and 1 more
$10,000of $10,000
Proposes a CpG-ODN-loaded PEI-PEG nanoparticle delivered intranasally to target lung-draining lymph nodes as a safer immunotherapy for lymphangioleiomyomatosis (LAM). Fits the RFP's innate sensing and checkpoint biology priorities and is backed by promising pilot data, but confirmatory power is limited by n=5 cohorts without a priori sizing and underspecified inflammation readouts.