$2of $165,000
Proposes using the open Cimbi dataset (N=1,100) with PET, rs-fMRI, and free-water dMRI plus blood and clinical data to cluster endogenous DMT brain biotypes. Fits the DMT Quest RFP and leverages a rich multi-modal dataset, but the chosen markers are not specific to DMT (largely serotonergic), and the $165K budget, 12-month timeline, and clustering plan are thinly justified.