We prove a non-existence theorem for smooth, supersymmetric, warped AdS6solutions with connected, compact without boundary internal space in D=11 and(massive) IIA supergravities. In IIB supergravity we show that if such AdS6solutions exist, then the NSNS and RR 3-form fluxes must be linearlyindependent and certain spinor bi-linears must be appropriately restricted.Moreover we demonstrate that the internal space admits an so(3) action whichleaves all the fields invariant and for smooth solutions the principal orbitsmust have co-dimension two. We also describe the topology and geometry ofinternal spaces that admit such a so(3) action and show that there are nosolutions for which the internal space has topology F * S^2, where F is anoriented surface.