We study the general effects of anomalous U(1)_A gauge symmetry on softsupersymmetry (SUSY) breaking terms in large volume scenario, where the MSSMsector is localized on a small cycle whose volume is stabilized by the D-termpotential of the U(1)_A. Since it obtains SUSY breaking mass regardless of thedetailed form of K\"ahler potential, the U(1)_A vector superfield acts as amessenger mediating the SUSY breaking in the moduli sector to the MSSM sector.Then, through the loops of U(1)_A vector superfield, there arise soft masses ofthe order of m_{3/2}^2/8\pi^2 for scalar mass squares, m_{3/2}/(8\pi^2)^2 forgaugino masses, and m_{3/2}/8\pi^2 for A-paramteres. In addition, the massiveU(1)_A vector superfield can have non-zero F and D-components through themoduli mixing in the K\"ahler potential, and this can result in larger softmasses depending upon the details of the moduli mixing. For instance, in thepresence of one-loop induced moduli mixing between the visible sector modulusand the large volume modulus, the U(1)_A D-term provides soft scalar masssquares of the order of m_{3/2}^2. However, if the visible sector modulus ismixed only with small cycle moduli, its effect on soft terms depends on how tostabilize the small cycle moduli.