Phenomenologically appealing supersymmetric grand unified theories have largegauge representations and thus are not asymptotically free. Their ultravioletvalidity is limited by the appearance of a Landau pole well before the Planckscale. One could hope that these theories save themselves, before the inclusionof gravity, by generating an interacting ultraviolet fixed point, similar tothe one recently discovered in non-supersymmetric gauge-Yukawa theories.Employing a-maximization, a-theorem, unitarity bounds, as well as positivity ofother central charges we nonperturbatively rule out this possibility for abroad class of prime candidates of phenomenologically relevant supersymmetricgrand unified theories. We also uncover candidates passing these tests, whichhave either exotic matter or contain one field decoupled from thesuperpotential. The latter class of theories contains a model with the minimalmatter content required by phenomenology.