Delta-Rice is an HDF5 (The HDF Group et al., 2020) filter plugin that was developed to compress digitized detector signals recorded by the Nab experiment (Fry et al., 2019), a fundamental neutron physics experiment.This is a two-step process where incoming data is passed through a pre-processing filter and then compressed with Rice coding.A routine for determining the optimal pre-processing filter for a dataset is provided along with an example GPU deployment.When applied to data collected by the Nab data acquisition system, this method produced output files 29% their initial size, and was able to do so with an average read/write throughput in excess of 2 GB/s on a single CPU.Compared to the widely used Gzip compression routine, Delta-Rice reduces the file size by 33% more with over an order of magnitude increase in read/write throughput.Delta-Rice is available on CPU to users through the HDF5 library.