Mangifera indica L., commonly known as mango, is a vital fruit crop in Pakistan, renowned for its rich nutritional profile and phytochemical composition. However, mangoes are susceptible to various phytopathogenic diseases, with anthracnose being a significant concern. This study investigated the impact of environmental factors, specifically temperature and humidity, on the development of mango anthracnose. Seven mango varieties (Duseri, Anwarlatore, Sindhri, Langra, Sammar, White Chunsa, and Fajr) were selected and surveyed in the Bahawalpur region, including Mubarakpur, Yazman, Ahmadpur East, Lalsuhanra, and Bahawalpur City. Tagged leaves exhibiting anthracnose symptoms were monitored to assess the disease's growth rate in response to environmental factors. Our findings suggest that optimal conditions in the Bahawalpur region facilitate the proliferation of mango anthracnose. Significantly, changes in rainfall patterns, potentially linked to global warming, contribute to the spread of anthracnose disease.