Abstract Because of the carbon macro-segregation inherent to the large thickness flat component manufacturing, the Fracture Mechanics Assessment (FMA) of the Steam Generator Tube-Sheet (SG-TS) was required for flaws postulated close to the primary (and cladded) surface or the secondary (non-cladded) surface in France. For those assessments, a flaw relying two holes is postulated, which represents a singular configuration compared to conventional FMA. Indeed the flaw is relatively small in comparison to the plate thickness and the crack length is limited by the distance between two holes. To take benefit of the geometry effect of this configuration, a methodology based on a modified global approach was proposed [1]. Applications of this methodology predict benefits of loss of constraint for several tubesheet configurations as underclad flaw or surface flaw with mechanical or thermomechanical loading. Significant constraint effect for underclad flaw and moderate effect for surface effect are estimated. To validate the relevance of this approach, two actions are undertaken: - In the first one, this methodology is applied on an experimental data base which different constraint effect. This data base contains numerous fracture tests performed by both EDF and Framatome on various specimen geometries extracted from a 18MND5 low alloy ferritic steel plate, in the brittle-to-ductile transition regime. C (T), SE(T), SE(B), and non-standard specimens. - In the second one, this application rule is validated through the interpretation of fracture tests performed in the brittle to ductile transition temperature range of specimen representative of a flaw between two isthmuses. The results obtained by this application appear accurate, providing very interesting perspectives for the assessment of the SG-TS, but also the assessment of other configurations such as small surface flaws configuration encountering constraint loss (loss of constraint called the small flaw effect).