Zirconium alloys are widely used in nuclear reactors as fuel cladding materials. Fuel cladding is used to contain the nuclear fuel and cladding tubes are typically sealed using welds. Welding of zirconium alloys can result in changes in the local microstructure, with the potential to grow so called 'blocky α' grains in the welded region during subsequent thermal processing and these blocky α grains have the potential to be detrimental to the integrity of the component. In this work, complimentary heating experiments with ex situ and in situ electron backscatter diffraction (EBSD) analysis are used to aid understanding of the blocky α grain growth within the weld region. These experiments reveal that blocky α grain growth is related to the prior-β (high temperature) microstructure, as grains grow adjacent to a prior-β grain boundary and the orientation of the growing α grain can be explained using neighbourhood orientations from this prior-β grain. This growth mechanism is explained via a simple mechanism which is related to the α grain orientations, grain boundary structures and local stored energy. Ultimately, our findings indicate that the likely grain growth (size and morphology) across the weld region can now be predicted from the initial as-welded microstructure.