Over the past two decades, extensive research has elucidated the significant contributions of various nanomaterial such as metals, metal oxides, carbon nanotubes (single, double, and multi-wall), nanowires, and graphene in improving the tribological and thermal properties of AC & R systems used in both industrial and domestic settings. A recent research paper has specifically focused on the performance enhancement of AAC through the use of Nano-oxides, namely CuO, ZnO, and TiO2, employing mathematical modeling. This study investigates how dispersed Nano-oxides of CuO, ZnO, and TiO2, when added to a base of POE lubricant and HFC-R134a refrigerant, influence the performance of automobile air conditioning systems. The primary focus is on viscosity, heat transfer rate, and thermal conductivity of the working medium. The experimental results are compared with tested data, and further analysis is conducted using TK Solver 6.0 and Origin Lab software. The findings demonstrate that the incorporation of these Nano-oxides has a positive impact on thermal-physical properties (k-Thermal conductivity, ρ-viscosity, ρ-density and Cp-specific-heat) and heat transfer characteristics compared to systems without Nano-materials. Furthermore, there is a notable increase in Coefficient of Performance (COP) ranging from 23–29% with varying volume concentrations of Nano-oxides (0.5% to 2.5%) under atmospheric temperature conditions. Consequently, the combination of copper oxide, Zinc Oxide, and Titania nanoparticles with HFC-R134a as well as R1234ze (E) proves to be an effective approach for optimizing refrigerant properties and improving the performance of automobile air conditioning systems. Thus, Nano-oxides dispersion offer a promising solution for enhancing energy efficiency and reducing the reliance on conventional energy sources in thermal systems.