In response to the lack of systematic planning in the welding workshop layout of a certain bogie frame, resulting in unreasonable workshop layout and unsmooth logistics, this paper proposes a simulation optimization method for workshop layout based on simulated annealing algorithm. Firstly, the workshop production simulation model is established on the basis of the detailed investigation of the workshop business, so as to realize the accurate simulation of the real workshop production.Then, aiming at the shortest transport distance, an improved simulated annealing algorithm is designed, and the field layout experience rules are summarized and added into the algorithm as the initialization method and heuristic operator. Finally, the algorithm is combined with the simulation model, the simulation model is used as a decoding tool, and the optimization framework based on intelligent algorithm is realized through algorithm iteration, and the optimal solution of the layout scheme is obtained.The optimized framework welding workshop layout scheme reduces the handling distance by about 16% compared to the current layout of the workshop under the same production plan, making the material transportation path more reasonable and bringing logistics benefits to the factory.