The paper reports the second case described in the literature of spondylodiscitis caused by Clostridium ramosum in an elderly immunocompetent patient affected by cellulitis of the left lower limb treated with triple antibiotic therapy (vancomycin, metronidazole and meropenem). The patient has shown a clinical and bio-humoral improvement after the treatment, even if he died after 16 days of hospitalization for severe sepsis of unknown origin.