Publish
Home
Live
new
RH Journal
ResearchCoin
Grants
Funding
Browse
Journals
Hubs
Tools
Lab Notebook
Beta
Reference Manager
Resources
Verify Identity
Community
Support
About
Terms
Privacy
Issues
Docs
Author
Log in
Sign up
MF
Michael Fountain
Author with expertise in Magnetic Resonance Imaging Applications in Medicine
Achievements
Cited Author
Open Access Advocate
Key Stats
Upvotes received:
0
Publications:
2
(50% Open Access)
Cited by:
587
h-index:
7
/
i10-index:
5
Reputation
Biology
< 1%
Chemistry
< 1%
Economics
< 1%
Show more
How is this calculated?
Overview
Publications
2
Peer Reviews
Comments
Grants
Publications
0
Time-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle
Britton Chance
et al.
Nov 1, 1988
Difficulties of quantitation of hemoglobin/myoglobin absorption changes in muscle have led to the development of a new approach using short pulses of light. This method uses input light pulses sufficiently short so that the time course of travel of light through the brain can be precisely measured. The time of arrival of light at the detector gives the optical path length, given the velocity of light in tissues. The intensity profile of photon migration in tissues permits determination of the path length that the exiting photons have traveled and the concentration change of the pigments. A cavity-dumped liquid dye laser illuminates the tissue with 130-ps pulses detected as 600-ps duration at a half height at 3.0-cm distance from the input point. The decay of intensity from the 50% point onward to 0.1% follows a logarithmic function of slope mu which is attributed to the total absorption coefficient of the tissue. Increments of mu due to deoxyhemoglobin absorption at 760 and 630 nm are used to calculate the concentration change. This permits the calculation of the path length for continuous light measurements of 2 cm for a particular geometry. Variation of the wavelength of the laser affords determination of a spectrum of changes in the tissue.
Biochemistry
Organic Chemistry
0
Paper
Biochemistry
330
0
Save
0
Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease
Adam Smith
et al.
Jan 19, 2010
Biochemistry
Pharmacology
0
Paper
Biochemistry
257
0
Save