In this paper we study the interplay between the recently proposed F-theoryGUTs and cosmology. Despite the fact that the parameter range for F-theory GUTmodels is very narrow, we find that F-theory GUTs beautifully satisfy mostcosmological constraints without any further restrictions. The viability of thescenario hinges on the interplay between various components of the axionsupermultiplet, which in F-theory GUTs is also responsible for breakingsupersymmetry. In these models, the gravitino is the LSP and develops a mass byeating the axino mode. The radial component of the axion supermultiplet knownas the saxion typically begins to oscillate in the early Universe, eventuallycoming to dominate the energy density. Its decay reheats the Universe to atemperature of ~ 1 GeV, igniting BBN and diluting all thermal relics such asthe gravitino by a factor of ~ 10^(-4) - 10^(-5) such that gravitinoscontribute a sizable component of the dark matter. In certain cases,non-thermally produced relics such as the axion, or gravitinos generated fromthe decay of the saxion can also contribute to the abundance of dark matter.Remarkably enough, this cosmological scenario turns out to be independent ofthe initial reheating temperature of the Universe. This is due to the fact thatthe initial oscillation temperature of the saxion coincides with the freeze outtemperature for gravitinos in F-theory GUTs. We also find that saxion dilutionis compatible with generating the desired baryon asymmetry from standardleptogenesis. Finally, the gravitino mass range in F-theory GUTs is 10-100 MeV,which interestingly coincides with the window of values required for the decayof the NLSP to solve the problem of Li(7) over-production.