Paper
Document
Submit new version
Download
Flag content
3

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Authors
Victoria Acosta-Rodríguez,Filipa Rijo-Ferreira
Mariko Izumo,Pin Xu,Mary Wight-Carter,Carla B. Green,Joseph S. Takahashi,Filipa Rijo‐Ferreira,Mary Wight‐Carter,Carla Green
+8 authors
,Joseph Takahashi
Journal
Published
Jun 10, 2022
Show more
Save
TipTip
Document
Submit new version
Download
Flag content
3
TipTip
Save
Document
Submit new version
Download
Flag content

Abstract

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising the question of if it is calories, fasting, or time of day that is the cause of this increased life span. We show here that 30% CR was sufficient to extend the life span by 10%; however, a daily fasting interval and circadian alignment of feeding acted together to extend life span by 35% in male C57BL/6J mice. These effects were independent of body weight. Aging induced widespread increases in gene expression associated with inflammation and decreases in the expression of genes encoding components of metabolic pathways in liver from ad libitum–fed mice. CR at night ameliorated these aging-related changes. Our results show that circadian interventions promote longevity and provide a perspective to further explore mechanisms of aging.

Paper PDF

Empty State
This PDF hasn't been uploaded yet.
Do not upload any copyrighted content to the site, only open-access content.
or