Abstract Background Community-based interventions may promote awareness and adherence to atrial fibrillation (AF)-related therapies, potentially reducing adverse events. The ARENA project investigated the health status, therapies and events in AF patients in the Rhein–Neckar Region, Germany. The subproject “ARENA intervention” studied the effect of community-based interventions on AF-associated outcomes. Methods From 2016 onward, patients with diagnosed AF were recruited for the observational ARENA registry. In 2018, an intervention period was initiated involving population-based information campaigns on AF diagnosis and therapies. The “control group” was recruited prior to initiation, and the “intervention group” afterward. Patients underwent standardized follow-up &gt; 1 year after recruitment. Clinical outcomes, therapy and quality of life were compared between the two groups. Results A total of 2769 patients were included. This real-world cohort showed high adherence to oral anticoagulation therapy (OAC) and an increased use of NOACs over vitamin K antagonists over time. In the intervention group ( n = 1362), more patients continued OAC at follow-up (87.1% vs. 81.5%, P = 0.002). However, this difference was not significant in the patient subgroup with class I/IIa indications for OAC (90.1% vs. 87.5%, P = 0.11). AF-related re-hospitalization was lower in the intervention group (6.8% vs. 12.3%, P &lt; 0.001). There was no significant difference in quality of life. AF-related anxiety was reduced at follow-up. Of note, nearly a quarter of all patients stated that ARENA had influenced their health perception. Conclusion Tailored community-based campaigns may raise awareness for AF-related health issues, supporting therapy adherence. Future public strategies to improve quality of life in AF patients should be investigated, as the ARENA project hints at a potential benefit of population-based campaigns. Trial registration ClinicalTrials.gov (Identifier: NCT02978248).

Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project