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The Molecular Taxonomy of Primary Prostate Cancer
Authors
Adam Abeshouse,Jaeil Ahn
Rehan Akbani,Adrian Ally,Samirkumar Amin,Chris Andry,Matti Annala,Armen Aprikian,Joshua Armenia,Arshi Arora,J. Auman,Miruna Balasundaram,Saianand Balu,Christopher Barbieri,Thomas Bauer,Christopher Benz,Alain Bergeron,Rameen Beroukhim,Mario Berríos,Adrian Bivol,Tom Bodenheimer,Lori Boice,Moiz Bootwalla,Rodolfo Reis,Paul Boutros,Jay Bowen,Reanne Bowlby,Jeffrey Boyd,Robert Bradley,Anne Breggia,Fadi Brimo,Christopher Bristow,Denise Brooks,Bradley Broom,Alan Bryce,Glenn Bubley,Eric Burks,Yaron Butterfield,M. Button,David Canes,Carlos Carlotti,Rebecca Carlsen,Michel Carmel,Peter Carroll,Scott Carter,Richard Cartun,Brett Carver,June Chan,Matthew Chang,Yu Chen,Andrew Cherniack,Simone Chevalier,Lynda Chin,Juok Cho,Andy Chu,Eric Chuah,Sudha Chudamani,Kristian Cibulskis,Giovanni Ciriello,Amanda Clarke,Matthew Cooperberg,Niall Corcoran,Anthony Costello,Janet Cowan,Daniel Crain,Erin Curley,Kerstin David,John Demchok,Francesca Demichelis,Noreen Dhalla,Rajiv Dhir,Alexandre Doueik,Bettina Drake,Heidi Dvinge,Natalya Dyakova,Ina Felau,Martin Ferguson,Scott Frazer,Stephen Freedland,Yao Fu,Stacey Gabriel,Jianjiong Gao,Johanna Gardner,Julie Gastier-Foster,Nils Gehlenborg,Mark Gerken,Mark Gerstein,Gad Getz,Andrew Mungall,Anuradha Gopalan,Markus Graefen,Kiley Graim,Thomas Gribbin,Ranabir Guin,Manaswi Gupta,Angela Hadjipanayis,Syed Haider,Lucie Hamel,D. Hayes,David Heiman,Julian Hess,Katherine Hoadley,Andrea Holbrook,Robert Holt,Antonia Holway,Christopher Hovens,Alan Hoyle,Mei Huang,Carolyn Hutter,Michael Ittmann,Lisa Iype,Joshua Stuart,Corbin Jones,Steven Jones,Hartmut Juhl,André Kahles,Christopher Kane,Katayoon Kasaian,Michael Kerger,Ekta Khurana,Jaegil Kim,Robert Klein,Raju Kucherlapati,Louis Lacombe,Marc Ladanyi,Phillip Lai,Peter Laird,Sı́lvia Beà,Mathieu Latour,Michael Lawrence,Kevin Lau,Tucker LeBien,Darlene Lee,Semin Lee,Kjong-Van Lehmann,Kristen Leraas,Ignaty Leshchiner,Robert Leung,John Libertino,Tara Lichtenberg,Pei Lin,W. Linehan,Shiyun Ling,Scott Lippman,Jia Liu,Wenbin Liu,Lucas Lochovsky,Massimo Loda,Christopher Logothetis,Laxmi Lolla,Teri Longacre,Yiling Lu,Jianhua Luo,Yussanne Ma,Harshad Mahadeshwar,David Mallery,Armaz Mariamidze,Marco Marra,Michael Mayo,Shannon McCall,Ginette McKercher,Shaowu Meng,Anne‐Marie Mes‐Masson,Maria Merino,Matthew Meyerson,Piotr Mieczkowski,Gordon Mills,Kenna Shaw,Sarah Minner,Alireza Moinzadeh,Richard Moore,Scott Morris,Carl Morrison,Lisle Mose,Bradley Murray,Jerome Myers,Rashi Naresh,Joel Nelson,Mark Nelson,Peter Nelson,Yulia Newton,Michael Noble,Houtan Noushmehr,Matti Nykter,Angeliki Pantazi,Michael Parfenov,Peter Park,Joel Parker,Joseph Paulauskis,Robert Penny,Charles Perou,Alain Piché,Todd Pihl,Peter Pinto,Davide Prandi,Alexei Protopopov,Nilsa Ramirez,Arvind Rao,W. Rathmell,Gunnar Rätsch,Xiaojia Ren,Victor Reuter,Sheila Reynolds,Suhn Rhie,Kimberly Rieger‐Christ,Jeffrey Roach,A. Robertson,Brian Robinson,Mark Rubin,Fred Saad,Sara Sadeghi,Gordon Saksena,Charles Saller,Andrew Salner,Francisco Sánchez-Vega,Chris Sander,George Sandusky,Guido Sauter,Andrea Sboner,Peter Scardino,Eleonora Scarlata,Jacqueline Schein,Thorsten Schlomm,Laura Schmidt,Nikolaus Schultz,Steven Schumacher,Jonathan Seidman,Luciano Neder,Sahil Seth,Alexis Sharp,Candace Shelton,Troy Shelton,Hui Shen,Ronglai Shen,Mark Sherman,Margi Sheth,Yan Shi,Juliann Shih,Ilya Shmulevich,Jeffry Simko,Ronald Simon,Janae Simons,Payal Sipahimalani,Tara Skelly,Heidi Sofia,Matthew Soloway,Xingzhi Song,Andrea Sorcini,Carrie Sougnez,Serghei Stepa,Chip Stewart,John Stewart,Travis Sullivan,Charlie Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Katherine Tarvin,Justin Taylor,Patrick Teebagy,Imelda Tenggara,Bernard Têtu,Ashutosh Tewari,Nina Thiessen,Timothy Thompson,Leigh Thorne,Daniela Tirapelli,Scott Tomlins,Felipe Trevisan,Patricia Troncoso,Lawrence True,Maria Tsourlakis,Svitlana Tyekucheva,Eliezer Allen,David Berg,Umadevi Veluvolu,Roel Verhaak,Cathy Vocke,Doug Voet,Yunhu Wan,Qingguo Wang,Wenyi Wang,Zhining Wang,Nils Weinhold,John Weinstein,Daniel Weisenberger,Matthew Wilkerson,Lisa Wise,John Witte,Chia-Chin Wu,Junyuan Wu,Ye Wu,Andrew Xu,Shalini Yadav,Liming Yang,Lixing Yang,Christina Yau,Huihui Ye,Peggy Yena,Thomas Zeng,Jean Zenklusen,Hailei Zhang,Jianhua Zhang,Jiashan Zhang,Wei Zhang,義夫 田中,Kelsey Zhu,Erik Zmuda,Arnoud Boot
+309 authors
,Andrew GodwinJournal
Published
Nov 1, 2015
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Abstract
Summary
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects.Paper PDF
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