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A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Authors
Nicole Almanzar,Stephen Chang
Ankit Baghel,Isaac Bakerman,Ishita Bansal,Ben Barres,Philip Beachy,Daniela Berdnik,Biter Bilen,Douglas Brownfield,Corey Cain,Charles Chan,Michelle Chen,Michael Clarke,Stephanie Conley,Spyros Darmanis,Aaron Demers,Kubilay Demir,Antoine Morrée,Taylor Divita,Haley Bois,Hamid Ebadi,F. Espinoza,Matt Fish,Qiang Gan,Benson George,Astrid Gillich,Rafael Gómez-Sjöberg,Foad Green,Geraldine Genetiano,Xueying Gu,Gunsagar Gulati,Oliver Hahn,Michael Haney,Yan Hang,Lincoln Harris,Mu He,Shayan Hosseinzadeh,Albin Huang,Kerwyn Huang,Tal Iram,Taichi Isobe,Feather Ives,Robert Jones,Kevin Kao,Jim Karkanias,Guruswamy Karnam,Andreas Keller,Aaron Kershner,Nathalie Khoury,Seung Kim,Bernhard Kiss,William Kong,Mark Krasnow,Maya Kumar,Christin Kuo,Jonathan Lam,Davis Lee,Song Lee,Benoit Lehallier,Olivia Leventhal,Guang Li,Qingyun Li,Ling Liu,Annie Lo,Wan-Jin Lu,Maria Lugo-Fagundo,Anoop Manjunath,Andrew May,Ashley Maynard,Aaron McGeever,Marina McKay,M. McNerney,Bryan Merrill,Ross Metzger,Marco Mignardi,Dullei Min,Ahmad Nabhan,Norma Neff,Katharine Ng,Patricia Nguyen,Joseph Noh,Roel Nusse,Róbert Pálovics,Rasika Patkar,Weng Peng,Lolita Penland,Angela Pisco,Katherine Pollard,Robert Puccinelli,Zhen Qi,Stephen Quake,Thomas Rando,Eric Rulifson,Nicholas Schaum,Joe Segal,Shaheen Sikandar,Rahul Sinha,Rene Sit,Justin Sonnenburg,Daniel Staehli,Krzysztof Szade,Michelle Tan,Weilun Tan,Cristina Tato,Krissie Tellez,Laughing Dulgeroff,Kyle Travaglini,Carolina Tropini,Margaret Tsui,Lucas Waldburger,Bruce Wang,Linda Weele,Kenneth Weinberg,Irving Weissman,Michael Wosczyna,Sean Wu,Tony Wyss‐Coray,Jinyi Xiang,Soso Xue,Kevin Yamauchi,Andrew Yang,Lakshmi Yerra,Justin Youngyunpipatkul,Brian Yu,Fabio Zanini,Macy Zardeneta,Alexander Zee,Chunyu Zhao,Fan Zhang,Hui Zhang,Martin Zhang,Lu Zhou,James Zou,Francisco Espinoza
+133 authors
,M Fish
Journal
Published
Jul 15, 2020
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Abstract

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing-such as senescence3, genomic instability4 and changes in the immune system2. This transcriptomic atlas-which we denote Tabula Muris Senis, or 'Mouse Ageing Cell Atlas'-provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

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