A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

Abstract

Research Article1 May 1989free access A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. I. Stamenkovic I. Stamenkovic Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author E. A. Clark E. A. Clark Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author B. Seed B. Seed Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author I. Stamenkovic I. Stamenkovic Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author E. A. Clark E. A. Clark Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author B. Seed B. Seed Department of Genetics, Harvard Medical School, Boston, MA. Search for more papers by this author Author Information I. Stamenkovic1, E. A. Clark1 and B. Seed1 1Department of Genetics, Harvard Medical School, Boston, MA. The EMBO Journal (1989)8:1403-1410https://doi.org/10.1002/j.1460-2075.1989.tb03521.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation. Previous ArticleNext Article Volume 8Issue 51 May 1989In this issue RelatedDetailsLoading ...