Motivation: Optimal treatment for GBM requires precise targeting of all viable tumor cells, many of which are not visible on conventional neuroimaging. Goal(s): We aimed to utilize WBSI to identify infiltrating tumor cells in GBM patients for selecting a precise target volume for personalized mapping of transducer arrays for enhanced delivery of TTFields. Approach: A mean value of choline/NAA was computed from normal mask, and all voxels that exceeded two-fold threshold value were included in a 3D-composite mask from the tumor region. Results: WBSI provided higher yield of voxels with good spectral quality, resulting in improved brain tumor coverage compared to anatomical MRI sequences. Impact: Alternative array configuration created from WBSI will allow precise delineation of tumor margins for enhanced delivery of TTFields dose to all proliferating regions of a GBM, decreasing the rate of local recurrence and ultimately improving overall survival.

Integration of Whole Brain Spectroscopic Imaging in Planning Workflow for Personalized Delivery of TTFields in Glioblastomas

Scan to connect with one of our mobile apps

Coinbase Wallet app

Coinbase app

Or try the Coinbase Wallet browser extension