In this Letter, we report the dark matter search results from the commissioning run (Run0) and the first science run (Run1) of the PandaX-4T experiment. The two datasets were processed with a unified procedure, with the Run1 data treated blindly. The data processing is improved compared to previous work, unifying the low-level signal reconstruction in a wide energy range up to 120 keV. With a total exposure of
1.54 tonne·year, no significant excess of nuclear recoil events is found. The lowest 90% confidence level exclusion on the spin-independent cross section is
1.6×10−47 cm2 at a dark matter mass of
40 GeV/c2. Our results represent the most stringent constraint for a dark matter mass above
100 GeV/c2. Published by the American Physical Society 2025